1. Make your vacations a REAL vacation.
Your out-of-office reply is there for a reason! Don't check you email every day or call in to see what is going on. Take a break... it'll make you stronger in the long run!
2. Give yourself a transition day or two.
Rather than coming home the night before you go back to work, give yourself time to run errands, pick up groceries, do laundry and gear up a bit.
3. Make a plan for your return.
Don't overbook yourself your first couple of days back at work. Carve out time to go through emails, dig through anything that accumulated on your desk and get back in the groove! Block out this time on your schedule so you don't get booked for meetings!